By David Hoffnung
Reducing the Risks of High Cortisol
Implicated in the onset of 95% of all cancers is a common but under-recognized molecule most people have never heard of: nuclear factor-kappaB or NF-kB.1-3 Emerging research is validating the danger it poses to maturing individuals.
For example, a landmark study4 published late last year confirmed, for the first time, NF-kB’s central role in the onset of malignant breast cancer.
A team of researchers found that breast cancer cells require a specific inflammatory cascade in order to proliferate and metastasize.
As one of the proteins that activates genes involved in inflammation, NF-kB is the master regulator of this pathologic cancer-causing process.
Fortunately, there exists a broad array of nutrients many Life Extension® members already take that have been shown to neutralize and even reverse the cancer-causing inflammatory cascade mediated by NF-kB.
In this article, a comprehensive survey of NF-kB-inhibiting compounds is detailed. You will learn how NF-kB triggers the growth and development of many kinds of tumors, operating as the master switch for cells “pre-loaded” with cancer-causing genes. You’ll also discover compelling evidence about low-cost interventions that suppress NF-kB, switch off lethal cancer genes, and disrupt the inflammatory cascade cancer cells need in order to spread.
Since its discovery in 1986, NF-kB has been known to be closely associated with development of cancer.5 Today we know that most, if not all cancers have abnormally high levels of active NF-kB, which keeps them in a state of sustained inflammation.6 Conversely, certain so-called oncogenes (abnormal genes that can initiate cancer development) act in part by activating NF-kB.7 Together these facts conspire to produce a steady stream of inflammatory and cancer-promoting cytokines within a growing tumor.8
The production of these cell signaling molecules makes it much more likely that a given cancer-prone cell will go on to form a malignant tumor. It can also mean that a given tumor is much more resistant to radiation and chemotherapy, since NF-kB generally promotes cancer cell survival.9
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