Fresh data on Alzheimer disease are presented in the report “Vitamin D3-enriched diet correlates with a decrease of amyloid plaques in the brain of A??PP transgenic mice.” According to the authors of recent research from Charleston, South Carolina, “In addition to its function in calcium and bone metabolism, vitamin D is neuroprotective and important for mitigating inflammation. Alzheimer’s disease (AD) is a progressive neurodegenerative disorder of the central nervous system, characterized by neuronal loss in many areas of the brain, and the formation of senile (neuritic) plaques, which increase in number and size over time.”
“The goal of this project was to investigate whether vitamin D3 supplementation would affect amyloid plaque formation in amyloid-?? protein precursor (A??PP) transgenic mice that spontaneously develop amyloid plaques within 3-4 months of birth. A??PP mice were fed control, vitamin D3-deficient or vitamin D3-enriched diets for five months, starting immediately after weaning. At the end of the study, the animals were subjected to behavioral studies, sacrificed, and examined for bone changes and brain amyloid load, amyloid-?? (A??) peptide levels, inflammatory changes, and nerve growth factor (NGF) content. The results obtained indicate that a vitamin D3-enriched diet correlates with a decrease in the number of amyloid plaques, a decrease in A?? peptides, a decrease in inflammation, and an increase in NGF in the brains of A??PP mice,” wrote J. Yu and colleagues, Medical University of South Carolina (see also Alzheimer Disease).